Differences between HPLC & GC

1. HPLC is useful for analysis of samples which are liable to decompose at higher temperatures. GC involves high temperatures so compounds are stable at such temperatures.
2. In HPLC the mobile phase is a liquid whereas in GC the mobile phase or carrier is a gas.
3. GC cannot be used for analysis of high molecular weight molecules whereas HPLC has applications for separation and identification of very high molecular weight compounds
4. Columns are different
5. GC is applied for analysis of volatile compounds whereas non volatile compounds can be easily analyzed on HPLC